Microbiology Practice Exam

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In the disease cycle of animal viruses (Lysogenic), uncoating takes place between which two stages?

Attachment and Penetration
Penetration and Biosynthesis
Assembly and Release
Entry and Integration

The correct answer is: Penetration and Biosynthesis

The uncoating of animal viruses during the lysogenic cycle occurs specifically between penetration and biosynthesis stages. After the virus has successfully penetrated the host cell, it must undergo uncoating to release its genetic material from the capsid. This is a crucial step that allows the viral nucleic acid to be accessible for replication and transcription. In the context of the lysogenic cycle, this stage results in the integration of the viral DNA into the host genome, which will later dictate how the virus behaves and can remain dormant until certain triggers activate its replication (the lytic cycle). Understanding this sequence clarifies the virus's interaction with the host cell and the subsequent phases of viral behavior and pathogenesis.