Microbiology Practice Exam

The correct answer is secondary syphilis. This stage of syphilis is characterized by systemic manifestations and can lead to a wide variety of symptoms, including a distinctive rash. One of the hallmark features of secondary syphilis is the development of mucous membrane lesions known as mucous membrane pemphigoid, along with a skin rash that often appears on the trunk and extremities, including the palms of the hands and soles of the feet. This specific presentation is an important clinical indicator of secondary syphilis and differentiates it from the other stages of the infection.

In contrast, primary syphilis typically presents with a single sore or ulcer at the site of infection (a chancre), and it is not known for causing widespread rashes or lesions. Tertiary syphilis occurs much later and can lead to severe complications affecting various organs, including the heart and nervous system, but does not usually present with the distinctive rash on palms and soles. Latent syphilis refers to a period where the infection is still present but asymptomatic, with no observable signs or symptoms, including rashes.